Descripción de la oferta
Join our group to develop an innovative immunotherapy platform of bispecific \"Immune Cell Recruiters\" (ICRs) to reprogram tumor vasculature and boost immune infiltration in a 3‑year funded position.Vacancy detailsWe are seeking a highly motivated, talented Postdoctoral Fellow to join our translational research program. The successful candidate will work on the TETIS project (\"Tumor Endothelium Targeted Immunotherapies\"). The primary objective of this project is to build and validate a modular engineering platform—Immune Cell Recruiter (ICR) technology—designed to equip tumor endothelial cells with missing chemokines and adhesion mediators. By doing so, we aim to overcome a major hurdle in cancer immunotherapy: the lack of effector immune cell infiltration into the tumor microenvironment. As a proof‑of‑concept, the project focuses heavily on Hepatocellular Carcinoma (HCC), a malignancy where tumor angiogenesis and specialized tumor-associated vessels play a crucial role.Research GroupThe position is based within the Dynamics of the Antitumor Immune Response Research Group at Cima Universidad de Navarra, integrated into the Cancer Center Clínica Universidad de Navarra in Pamplona, Spain. Led by Dr. Álvaro Teijeira, the laboratory specializes in leveraging advanced optical imaging and intravital microscopy to directly observe immune cell behavior and traffic within the tumor microenvironment in real time. The group focuses on uncovering the mechanisms that govern leukocyte recruitment and identifying the structural/functional limitations that tumor vessels impose on the immune system. By understanding these barriers, the lab designs targeted immunotherapies to maximize infiltration of anti‑tumor immune cells. The candidate will work within a multidisciplinary consortium, linking CIMA’s imaging and immunotherapy expertise with chemical biology, nanobody engineering, and multi‑omics platforms across partner networks.ResponsibilitiesEstablish and execute in vitro and in vivo screening assays using endothelial cell monolayers to evaluate the recruitment capability of newly generated bispecific constructs and test candidate ICR molecules in subcutaneous tumor models and advanced transgenic models of HCC.Perform deep in vivo mechanistic assays, including evaluation of immune cell infiltration using flow cytometry and custom multiplex immunofluorescence panels, leveraging confocal and intravital microscopy to monitor immune‑endothelial dynamics.Participate actively in consortium milestones, generating high‑quality data for intellectual property protection and the preparation of high‑impact scientific manuscripts.Write and revise manuscripts and projects to advance your academic career; co‑mentor graduate and MSc students.TermsFull‑time, temporary postdoctoral research contract aligned with the project timeline (3 years, starting January 2027). Competitive salary commensurate with qualifications and experience, fully funded within the grant guidelines. It is expected that the candidate will apply to other sources of funding within the project timeline.RequirementsPh.D. in Immunology, Cancer Biology, Biomedicine, Biotechnology, or a related Life Sciences discipline (must be fully completed prior to the contract start date).Proven hands‑on experience with in vivo mouse models, including mouse handling, tumor inoculation, and drug administration.Valid official certification/license to perform animal experimentation (FELASA category B/C or equivalent Spanish functions B, C, D).Highly motivated, independent thinker with a strong proactive attitude and a collaborative spirit suitable for a multi‑center research consortium.High proficiency in written and spoken English for scientific reporting, presentations, and team communication.Highly Valued (Non‑Mandatory) RequirementsPrior experience in cancer immunology, immunotherapy, or vascular biology.Familiarity with advanced cellular biology techniques such as multi‑color flow cytometry, multiplex immunofluorescence, and in vitro functional cell assays.Experience or strong interest in advanced imaging techniques (confocal, spinning disk, or intravital live imaging).Track record with first‑author publications and other publications allowing the applicant to apply for competitive grants.Genuine interest in pursuing an academic career.Required application documents, including a detailed CV and letters of recommendation, must be uploaded directly via the Talent Clue platform to be considered for evaluation.
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